Is CBD Safe at High Doses?
CBD is safe. That's the conclusion of multiple studies done over the past decade which have looked into the safety of using CBD at high doses.
Over the past 10 years, interest in CBD's therapeutic properties has grown significantly. This is mostly due to the fact that CBD has been shown to offer many of same benefits as medical marijuana, but without serious side effects. CBD is completely non-toxic. There are no reported cases of overdose or death as a result of using CBD. For this reason, 18 US states have implemented CBD-only medical cannabis programs.
How safe is CBD?
Investigations into the safety of CBD as a therapeutic compound have suggested that CBD provides numerous therapeutic benefits, including anti-inflammatory, anti-diabetic, anti-epileptic, and anti-cancer properties while causing no serious side effects. On the other hand, THC has been shown in numerous studies to have undesirable side effects such as intoxication, anxiety, psychosis, sedation, and increased heart rate.
For example, a report published by Current Pharmaceutical Design described a double-blind, randomized trial done at London's King's College to determine the physiological and behavioral effects of both CBD and THC. What was most striking in this case was the difference in dosage. Just 10 mg of THC was shown to cause various physiological and behavioral effects such as increased heart rate and sedation. On the other hand, subjects receiving CBD were given 600mg, a full 60 times as much CBD as the subjects who were given THC. The mental and physiological effects of CBD turned out to be no different from those of the group that received a placebo.
You can read the full text of the study, “Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers” here.