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CBD Oil and Prescription Drugs

Does CBD Oil Have Any Adverse Drug Interactions?

When taking CBD to treat a medical condition, it’s important to know whether or not it can interact chemically with other medications. Some interactions may be beneficial to a person, while others can be highly dangerous. Moreover, specific drug effects may increase while others may result in a decreased effect. In some people, a new effect can also be produced which is not characteristic of either substance.

Drug interactions may also result from certain foods, called drug-food interactions, and medicinal plants or herbs, known as drug-plant interactions. As an example, antidepressant drugs such as monoamine oxidase inhibitors interact negatively with foods high in tyramine, such as aged cheese.

What Research Says About CBD-Drug Interactions

Although little research exists in this area, it is possible for CBD to affect the metabolization of some prescription drugs. Again, depending on the drug, these effects may be either beneficial or unwanted. For example, blood thinners such as Warfarin may be affected by the use of CBD, causing an increase in the time required for the drug to metabolize.

In a paper by the Washing D.C. Department of Health entitled, “Medical Cannabis - Adverse Effects & Drug Interactions,” the authors point out that CBD inhibits compounds which are involved in the metabolism of certain drugs, most notably CYP3A4 and CYP2D6. As a result, the time required to metabolize certain drugs is extended. The researchers also point out that about a quarter of all drugs are metabolized by CPY3A4. Depending on the desired effects, however, these results can be either positive or negative.

In a more recent report published by researchers at the University of Alabama at Birmingham entitled, “Interactions between cannabidiol and commonly used antiepileptic drugs,” authors claimed to have found evidence that CBD alters the blood levels of common antiepileptic drugs, causing changes in blood levels. Some of these drugs include clobazam, topiramate, rufinamide, zonisamide, and eslicarbazepine. However, none of them, with the exception of clobazam, showed levels outside a normal range.

Always Consult A Doctor

There is, as of yet, no known dangers from the interactions between CBD and prescription drugs, though more research is required on this topic. Determining all of the potential drug interactions involving CBD is a monumental task.

Although the chances of an adverse interaction are minuscule, it’s important for everyone to discuss their conditions with a qualified medical professional who is well-versed in the use of CBD. Anyone taking CBD in conjunction with other prescription medications should also monitor themselves for any signs or symptoms of an adverse reaction and contact their doctor immediately before stopping any medications.